An update on efficacy and safety of alpha-blockers in the treatment of distal ureteric stones: narrative review

Abstract Background Alpha-blockers prescribed as medical expulsion therapy (MET) have replaced minimally invasive procedures the primary line of treatment for minor ureteric stones. This study aims to investigate efficacy MET with alpha-blockers in terms stone rate and time evaluate safety several alpha-blockers. Methodology Google Scholar, PubMed, Web Science databases were searched relevant publications using keywords published between December 2013 August 2021. Additional research was found by looking through references articles. Results To determine a expulsive management distal ureteral stones, 15 studies included, 12 randomized control trials, 2 retrospective observational studies, 1 prospective study. The most commonly studied endpoint time. According findings, silodosin appears be more effective than other data revealed no life-threatening adverse effects associated Conclusion are recommended first-line Silodosin efficacious medicine, according data. side alpha-blockers, on hand, minor, consisting primarily orthostatic hypotension. alpha-blocker choice differs from urologist MET, depending their experience patient's condition.